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Trouble at the top as another one bites the dust in Downing Street. Just what is going on behind the door of Number 10? And will AI mine the human soul and use it to manipulate us? A concerned AI researcher speaks to Newsnight after quitting her job at OpenAI in protest. Plus the threshold at which graduates in England and Wales need to repay their loans is about to be frozen. How much will it add to their debt? With Paddy O'Connell